“Tonight, Electro dances with the gods!”
For a while, that is. Spider-Man 2: Enter Electro (2001) was initially released on August 2001 but was recalled after the September 11th attacks of that same year for these reasons and here is the biggest pre-9/11 and post-9/11 change for the game.
In the final boss battle, Electro landed on the World Trade Center and became an almighty being of electricity, where Spider-Man should defeat him on top of the World. Just before the battle, Spider-Man remarked to Electro, “Where would you be on top of the World?”
In the final boss battle, the World Trade Center is not seen and mentioned. However, it was redesigned in the game to make it look like a generic skyscraper with a bridge.
After that significant change, the game was finally released in October 2001 without any references to the event and the World Trade Center for a great effect.