The Powerpuff Girls (1998-2005) has been a cornerstone of animation and somewhat kid-friendly programming since its debut. It helped inspire a 2002 theatrical prequel film and a 2016 parallel universe that also aired on Cartoon Network.
As in the film, it is about three girls created from sugar, spice, everything nice and Chemical X, which made them have similar abilities to iconic superheroes such as Superman.
However, Craig McCracken clearly intended it to be an adult cartoon because of his 1992 test reel and the content shown in the show including Sara Bellum (Jennifer Martin), whose face is not seen at all and HIM (Tom Kane), a somewhat transphobic depiction of Satan.
However, HIM’s voice was inspired by The Beatles’ Yellow Submarine (1968) character known as the chief of the Blue Meanies.
Regardless of the violence and suggestive content, The Powerpuff Girls is a well-written cartoon that echoes feminism that would make Joss Whedon smile.